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About Modafinil – Modawake.com

Molecule - Modafinil
Thresh   Common   Heavy  
25 - 50 - 100 - 200 - 300 mg
   

Light

  Strong  

Modafinil Summary
 
Psychoactive class: Eugeroic

Chemical class: Benzhydryl

Oral

  • Total: 5 – 10 hours
  • Onset: 20 – 60 minutes
  • Come up: 20 – 60 minutes
  • Peak: 3.5 – 5 hours
  • Offset: 1 – 3 hours
  • Afterglow: 2 – 6 hours

Harm potential

  • Not addictive with a low potential for abuse

  • The median lethal dose at which percentage of participants die (LD5Array) from Modafinil for human beings has never been reached

Tolerance

  • Full tolerance is reached develops with prolonged and repeated use
  • Decreases to half after 3 – 7 days
  • Returns to baseline after 1 – 2 weeks
  • Cross-tolerance with all benzhydryl nootropics

Physical effects

  • Stimulation
  • Appetite suppression

Cognitive effects

  • Wakefulness
  • Thought acceleration
  • Memory enhancement
  • Increased music appreciation
  • Focus enhancement
  • Time distortion
  • Emotion enhancement

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.

 
Dosage
Threshold 25 – 50 mg
Light 50 – 100 mg
Common 100 – 200 mg
Strong 200 – 300 mg
Heavy 300 mg +
Duration
Total 5 – 10 hours
Onset 20 – 60 minutes
Come up 20 – 60 minutes
Peak 3.5 – 5 hours
Offset 1 – 3 hours
After effects 2 – 6 hours

DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only.  It is not a recommendation and should be verified with other sources for accuracy.


Chemistry

Physical effects

  • Stimulation – In terms of its effects on the user’s physical energy levels, Modafinil is commonly considered stimulating and energetic, but can be considered as less stimulating when compared to amphetamine.  This stimulation encourages physical movement and activities such as running, playing sports, socializing, and/or exercising.  The particular style of stimulation which Modafinil presents can result in jaw clenching, teeth grinding, or other involuntary movements comparable to that of traditional stimulants at high doses, but are manifested much less consistently and intensely when compared to amphetamine or cocaine.
    Body odour alteration – Modafinil can leave a very distinct smell of sulphur in one’s urine.  This is likely because Modafinil, being a member of the sulphinyl benzhydryl chemical class, contains sulphur in its chemical makeup.[12]
  • Body odor alteration – Modafinil can leave a very distinct smell of sulfur in one’s urine. This is likely because Modafinil, being a member of the sulphinyl benzhydryl chemical class, contains sulfur in its chemical makeup.[12]
  • Pupil dilation

Cognitive effects

  • Wakefulness
  • Focus enhancement
  • Thought acceleration
  • Memory enhancement
  • Motivation enhancement
  • Time distortion
  • Emotion enhancement or Emotion suppression
  • Increased music appreciation – While Modafinil is capable of producing this effect, it does not do so as reliably as it does with traditional stimulants or entactogens.

Tolerance and addiction potential

The chronic use of Modafinil is not addictive and carries a low potential for abuse.  It does not seem to be capable of causing psychological dependence among most users.

Tolerance to many of the effects of Modafinil develops with prolonged and repeated use.  This results in users having to administer increasingly large doses to achieve the same effects.  After that, it takes about 3 – 7 days for the tolerance to be reduced to half and one – 2 weeks to be back at baseline (in the absence of further consumption).  Modafinil may present a cross-tolerance with all benzhydryl nootropics, meaning that after the consumption of Modafinil, all related Eugeroic compounds such as Armodafinil and Adrafinil will display a reduced effect.

References

  1. Provigil (Manufacturer’s Website) | http://www.provigil.com/
  2. Modafinil augmentation of selective serotonin reuptake inhibitor therapy in MDD partial responders with persistent fatigue and sleepiness (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17729016
  3. A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17671288
  4. Neuroprotective effects of modafinil in a marmoset Parkinson model: behavioral and neurochemical aspects (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16940766
  5. PubMed – Modafinil treatment in patients with seasonal affective disorder/winter depression: an open-label pilot study (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/15306145
  6. Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/18280848
  7. 7.0 7.1 Morrissette, D. A. (2013). Twisting the night away: a review of the neurobiology, genetics, diagnosis, and treatment of shift work disorder. CNS Spectrums, 18(s1), 42–54. https://doi.org/10.1017/S109285291300076X
  8. Touitou, Y., & Bogdan, A. (2007). Promoting adjustment of the sleep-wake cycle by chronobiotics. Physiology and Behavior, 90(2–3), 294–300. https://doi.org/10.1016/j.physbeh.2006.09.001
  9. 9.0 9.1 Darwish, M., Kirby, M., D’Andrea, D. M., Yang, R., Hellriegel, E. T., & Robertson, P. (2010). Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: A randomized, open-label, crossover study. Clinical Therapeutics, 32(12), 2074–2087. https://doi.org/10.1016/j.clinthera.2010.11.009
  10. Erman MK, Yang R, Seiden DJ. The effect of armodafinil on patient-reported functioning and quality of life in patients with excessive sleepiness associated with shift work disorder: a randomized, double-blind, placebo-controlled trial. Prim Care Companion CNS Disord. 2012;14(4) . doi:10.4088/pcc.12m01345. PMID: 23251870; PMCID: PMC3505139.
  11. He, B., Peng, H., Zhao, Y., Zhou, H., & Zhao, Z. (2011). Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression. Brain Research, 1426, 38–42. https://doi.org/10.1016/j.brainres.2011.09.002
  12. Udert, K. M., Larsen, T. A., & Gujer, W. (2006). Fate of major compounds in source-separated urine. Water Science and Technology, 54(11–12), 413–420. https://doi.org/10.2166/wst.2006.921
  13. Pharmacotherapy for excessive daytime sleepiness | http://www.smrv-journal.com/article/S1087-0792(04)00024-3/abstract
  14. The National Library of Medicine – PROVIGIL | http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fd75a8a7-a8ab-4141-9af9-989a220b9c19
  15. Journal of Clinical Sleep Medicine – Unsuccessful Suicide Attempt of a 15 Year Old Adolescent with Ingestion of 5000 mg Modafinil http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725258
  16. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089
  17. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  18. Robertson, P (2002). “Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers”. Clinical Pharmacology Therapeutics. Springer Nature. 71 (1): 46–56. doi:10.1067/mcp.2002.121217. ISSN 0009-9236. 
  19. Bailey, D. G.; Dresser, G.; Arnold, J. M. O. (2012-11-26). “Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?”. Canadian Medical Association Journal. Joule Inc. 185 (4): 309–316. doi:10.1503/cmaj.120951. ISSN 0820-3946. 
  20. Modafinil Wikipedia | https://en.wikipedia.org/wiki/Modafinil
  21. National Association of Pharmacy Regulatory Authorities – Regulations Amending the Food and Drug Regulations (1184 — Modafinil) | http://napra.ca/Content_Files/Files/FDR-Project1184-Modafinil-Oct122006.pdf
  22. https://www.gesetze-im-internet.de/amvv/BJNR363210005.html
  23. “Narcotics”. 
  24. MHRA (April 3, 2013). “MHRA license for Modafinil in UK” (PDF). MHRA. 
  25. “Medicines Act 1968 Section 13”. 
  26. Placement of Modafinil Into Schedule IV – U.S. Department of Justice | http://www.deadiversion.usdoj.gov/fed_regs/rules/1999/fr0127.htm

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